Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway.
In humans, paralytic poliomyelitis results from the invasion of the central nervous system by circulating poliovirus (PV) via the blood-brain barrier (BBB).After the virus enters the central nervous system (CNS), it replicates in neurons, especially in motor neurons (MNs), inducing the cell death that causes paralytic poliomyelitis.Along with this